Category: BIS Member Paper Highlight
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BIS Member Paper Higlight: Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment, Genome Med, 2025.
Abstract. Monocytes are recruited to tumors and undergo transcriptional reprogramming resulting in tumor-promoting functions. It remains unknown whether systemic tumor-derived signals could alter the epigenomic landscape of peripheral monocytes before they reach the tumor, thus shaping their subsequent response to the tumor microenvironment. Here, we performed genome-wide analyses of multiple histone modifications (H3K4me1, H3K4me3, H3K27ac)…
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BIS Member Paper Higlight: Depleting IL1R2+ Tumor-Infiltrating Regulatory T Cells with an ADCC-Prone Nanobody Construct Boosts the Efficacy of Anti-PD1 Immunotherapy, Arnouk et a., Cancer Res 2025
Abstract. Eliminating immunosuppressive cells, such as regulatory T cells (Tregs), is a promising approach to boost immunotherapy success. However, this approach may suffer from systemic auto-immune adverse events, highlighting the need to specifically target tumor-infiltrating (ti)Tregs. We identified IL1R2 as a surface marker that was most highly expressed by activated and strongly T-cell suppressive tiTregs…
Belgian Immunological Society 